Description

1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-4-Hydroxy-8-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex bicyclic β-lactam structure. This compound is critical for the synthesis of novel carbapenem and penem antibiotics, offering a key building block for developing next-generation antimicrobial agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new antibacterial drugs to combat resistant pathogens.

Application

• Key Intermediate for Carbapenem Antibiotics: Serves as a crucial precursor in the multi-step synthesis of broad-spectrum carbapenem antibiotics like meropenem and ertapenem.
• Penem Antibiotic Synthesis: Used in the research and production of penem-class antibacterial compounds, known for their stability against β-lactamases.
• Pharmaceutical Research & Development (R&D): A vital scaffold for medicinal chemists exploring new β-lactam structures with enhanced activity and pharmacokinetic profiles.
• Antimicrobial Resistance (AMR) Research: Employed in the development of new therapeutic agents targeting multidrug-resistant bacterial infections.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes and scaling up production for commercial pharmaceutical manufacturing.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-4-Hydroxy-8-Oxo-
CAS No.	84414-81-3
Molecular Formula	C8H10N2O4
Molecular Weight	198.18 g/mol
Synonyms	(5R,6S)-6-[(R)-1-Hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (related core structure); 7-Amino-4-hydroxy-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 4-Hydroxy-7-amino-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Carbapenem Intermediate; Penem Intermediate; 84414-81-3; 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-4-hydroxy-8-oxo-
EINECS	Contact for details

Quality Control

Our 1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylicacid,7-Amino-4-Hydroxy-8-Oxo- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are available for every shipment. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.