Description

n-Boc-Piperidine-4-Carboxylic Acid is a protected amino acid derivative that serves as a crucial building block in organic synthesis. This compound is essential for the efficient and selective construction of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of piperidine-containing drug candidates, including kinase inhibitors, receptor antagonists, and central nervous system (CNS) active compounds.
• Peptidomimetics Synthesis: Used to introduce constrained, unnatural amino acid motifs into peptide backbones to enhance stability, bioavailability, and biological activity.
• Combinatorial Chemistry: Employed in solid-phase and solution-phase parallel synthesis libraries for high-throughput screening and drug discovery.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides that incorporate the piperidine scaffold.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and the scale-up production of specialized fine chemicals.

Basic Information

Product Name	n-Boc-Piperidine-4-Carboxylic Acid
CAS No.	84358-13-4
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	1-Boc-4-Piperidinecarboxylic Acid; 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic Acid; 4-Carboxy-1-piperidinecarboxylic Acid tert-Butyl Ester; tert-Butyl 4-carboxypiperidine-1-carboxylate; 1-N-Boc-piperidine-4-carboxylic Acid; N-Boc-isonipecotic Acid; Boc-Pip-OH; Boc-4-Piperidinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our n-Boc-Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	136 - 140 °C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.