Description

5-Pyrimidinecarboxamide, n-((1-Benzyl-2-Pyrrolidinyl)Methyl)-2-(Dimeth Ylamino)-4-Methoxy-, Dihydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. Its value lies in its role as a critical building block for the synthesis of advanced antiviral and antiretroviral active pharmaceutical ingredients (APIs). This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation HIV treatments and other therapeutic agents targeting viral replication.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs.
• Antiviral API Synthesis: Critical building block for the production of active pharmaceutical ingredients (APIs) used in antiretroviral therapies, particularly for HIV treatment.
• Medicinal Chemistry Research: Serves as a valuable scaffold for drug discovery programs focused on viral diseases and enzyme inhibition.
• Process Development & Scale-Up: Used in pilot plants and commercial manufacturing for optimizing synthetic routes to complex therapeutic molecules.
• Reference Standard: Can be utilized as an analytical standard for quality control and regulatory compliance in API production.

Basic Information

Product Name	5-Pyrimidinecarboxamide, n-((1-Benzyl-2-Pyrrolidinyl)Methyl)-2-(Dimeth Ylamino)-4-Methoxy-, Dihydrochloride
CAS No.	84332-26-3
Molecular Formula	C20H29N5O2 · 2HCl
Molecular Weight	460.40 g/mol (as free base: 387.48 g/mol)
Synonyms	Delavirdine Intermediate; U-90152S Intermediate; BHAP Intermediate (Bis(heteroaryl)piperazine); N-((1-Benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-5-pyrimidinecarboxamide dihydrochloride; Delavirdine Mesylate Intermediate; Rescriptor Intermediate; NSC 339768; 4-Methoxy-N-[(2S)-1-(phenylmethyl)-2-pyrrolidinyl]methyl]-2-(dimethylamino)-5-pyrimidinecarboxamide dihydrochloride
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR, and stringent control of residual solvents and impurities to meet the exacting standards required for API synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with cGMP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.