Description

Bis[(-)-1-[5-Chloro-2-(Methylamino)Phenyl]-1,2,3,4-Tetrahydroisoquinolinium] [R-(R*,R*)]-Tartrate is a high-purity chiral salt form of a tetrahydroisoquinoline derivative, designed for advanced pharmaceutical research and development. This compound is critical for its role as a key intermediate or reference standard in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring enantiomerically pure building blocks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel therapeutic agents.
• Reference Standard: Used for analytical method development, validation, and quality control in API manufacturing.
• Drug Discovery Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Acts as a starting material or intermediate in the scale-up and optimization of synthetic routes for GMP production.
• Asymmetric Synthesis: Utilized in catalytic or stoichiometric reactions requiring enantioselective control.
• Neurological & Cardiovascular Research: Investigated for potential activity in relevant biological assays and preclinical models.

Basic Information

Product Name	Bis[(-)-1-[5-Chloro-2-(Methylamino)Phenyl]-1,2,3,4-Tetrahydroisoquinolinium] [R-(R*,R*)]-Tartrate
CAS No.	84304-22-3
Molecular Formula	C₄₀H₄₄Cl₂N₄O₆
Molecular Weight	735.71 g/mol
Synonyms	(-)-1-(5-Chloro-2-(methylamino)phenyl)-1,2,3,4-tetrahydroisoquinoline (R,R)-tartrate (2:1 salt); (R,R)-Tartaric acid salt of 1-(5-Chloro-2-(methylamino)phenyl)-1,2,3,4-tetrahydroisoquinoline; Tetrahydroisoquinolinium tartrate derivative; CAS 84304-22-3; 5-Chloro-2-(methylamino)phenyl tetrahydroisoquinoline tartrate; Chiral tetrahydroisoquinoline salt; L-771,688 (related research compound analog).
EINECS	Contact for details

Quality Control

Our Bis[(-)-1-[5-Chloro-2-(Methylamino)Phenyl]-1,2,3,4-Tetrahydroisoquinolinium] [R-(R*,R*)]-Tartrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider handling under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.