Description

Insulin, Trp(A1)- is a chemically modified insulin analogue where the amino acid at the A1 position is substituted with tryptophan. This specific modification is of significant interest in biochemical and pharmaceutical research for studying insulin structure-activity relationships and receptor binding mechanisms. It serves as a critical tool compound for researchers and developers in the life sciences sector, particularly those focused on diabetes research, peptide hormone engineering, and metabolic disorder therapeutics.

Application

• Biochemical Research: Used as a reference standard and tool compound for investigating insulin's structure, function, and interaction with the insulin receptor.
• Pharmaceutical Development: Serves as a key intermediate or model compound in the research and development of novel insulin analogues and peptide-based therapeutics.
• Metabolic Studies: Employed in in vitro and ex vivo studies to understand insulin signaling pathways and mechanisms related to diabetes and other metabolic disorders.
• Analytical Standard: Utilized as a high-purity standard in chromatographic (HPLC, LC-MS) and spectroscopic analyses for method development and quality control of insulin-related products.
• Academic Research: A vital reagent for university and institutional labs conducting fundamental research in endocrinology, peptide chemistry, and molecular biology.

Basic Information

Product Name	Insulin, Trp(A1)-
CAS No.	84134-95-2
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.5 g/mol (approx.)
Synonyms	A1-Tryptophan Insulin; Insulin (human) Trp(A1); [TrpA1]-Insulin; Tryptophan A1 Insulin; Human Insulin A1-Tryptophan Analogue; Insulin Trp-A1; [Trp1]-Insulin A-chain; Insulin variant with Trp at position 1 of the A-chain
EINECS	Contact for details

Quality Control

Our Insulin, Trp(A1)- is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances. While typically supplied as a research-grade material, production can adhere to cGMP guidelines for advanced development purposes upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 10.0%
Biological Activity	Assessed by receptor binding assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.