Description

trans-(-)-3-Methyl-4-Phenyl-1-(p-Tolylsulphonyl)Piperidine-4-Carboxylic Acid is a high-purity, chiral piperidine derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in its defined stereochemistry and functionalized structure, enabling the construction of complex molecules with precise spatial orientation. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active pharmaceutical ingredients (APIs) and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel therapeutic agents, including central nervous system (CNS) drugs and receptor modulators.
• Agrochemical Research: Used in the development of enantiomerically pure pesticides and herbicides, where specific stereochemistry is crucial for bioactivity.
• Catalyst & Ligand Synthesis: Serves as a precursor for creating sophisticated chiral ligands used in asymmetric catalysis.
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for method development and quality control.
• Academic & R&D: A valuable tool for synthetic organic chemists in universities and corporate R&D for exploring new reaction pathways and compound libraries.
• Fine Chemical Production: Integrated into multi-step syntheses for producing specialty chemicals with high added value.

Basic Information

Product Name	trans-(-)-3-Methyl-4-Phenyl-1-(p-Tolylsulphonyl)Piperidine-4-Carboxylic Acid
CAS No.	83863-68-7
Molecular Formula	C20H23NO4S
Molecular Weight	373.47 g/mol
Synonyms	(-)-trans-3-Methyl-4-phenyl-1-(p-tolylsulfonyl)piperidine-4-carboxylic acid; trans-(-)-3-Methyl-4-Phenyl-1-(p-Toluenesulfonyl)Piperidine-4-Carboxylic Acid; (3R,4S)-3-Methyl-4-phenyl-1-tosylpiperidine-4-carboxylic acid; 1-(4-Methylphenyl)sulfonyl-3-methyl-4-phenyl-4-piperidinecarboxylic acid, trans-(-)-; trans-3-Methyl-4-phenyl-1-(p-tolylsulfonyl)piperidine-4-carboxylic acid; (-)-trans-3-Methyl-4-phenyl-1-tosylpiperidine-4-carboxylic acid; 83863-68-7
EINECS	Contact for details

Quality Control

Our trans-(-)-3-Methyl-4-Phenyl-1-(p-Tolylsulphonyl)Piperidine-4-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.