Description

1-(p-Tolylsulphonyl)-4-[3-(Trifluoromethyl)Phenyl]Piperazine is a high-purity, synthetic organic compound featuring a piperazine core substituted with a tosyl protecting group and a trifluoromethylphenyl moiety. This specific molecular architecture makes it a critical advanced intermediate for pharmaceutical research and development, particularly in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its piperazine scaffold and fluorine-containing aromatic group.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential APIs, requiring consistent high purity and reliable supply.
• Reference Standard: Acts as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Biochemical Tool Compound: Potential use in pharmacological assays and as a probe for studying specific biological pathways.

Basic Information

Product Name	1-(p-Tolylsulphonyl)-4-[3-(Trifluoromethyl)Phenyl]Piperazine
CAS No.	83863-48-3
Molecular Formula	C18H19F3N2O2S
Molecular Weight	384.42 g/mol
Synonyms	1-Tosyl-4-(3-(trifluoromethyl)phenyl)piperazine; 4-(3-(Trifluoromethyl)phenyl)-1-(4-methylphenyl)sulfonylpiperazine; 1-(4-Methylphenyl)sulfonyl-4-[3-(trifluoromethyl)phenyl]piperazine; N-[3-(Trifluoromethyl)phenyl]-N'-(p-tolylsulfonyl)piperazine; 4-(3-Trifluoromethylphenyl)-1-tosylpiperazine; 83863-48-3; Piperazine, 1-[(4-methylphenyl)sulfonyl]-4-[3-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 1-(p-Tolylsulphonyl)-4-[3-(Trifluoromethyl)Phenyl]Piperazine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.