Description

Leukotriene F4 is a potent bioactive lipid mediator belonging to the cysteinyl leukotriene family, derived from arachidonic acid metabolism. This compound is of significant interest in biochemical and pharmacological research due to its role in inflammatory and allergic responses, including bronchoconstriction and vascular permeability. It is a critical reference standard and intermediate for researchers and developers in the pharmaceutical, biotechnology, and life science sectors studying respiratory diseases, inflammation pathways, and drug discovery.

Application

• Biochemical Research: Used as a high-purity reference standard in studies of arachidonic acid metabolism and the 5-lipoxygenase pathway.
• Pharmacological Studies: Serves as a key intermediate or analytical standard in the development and testing of leukotriene receptor antagonists and biosynthesis inhibitors.
• Inflammation & Immunology Research: Essential for in vitro and in vivo models investigating the mechanisms of asthma, allergic rhinitis, and other inflammatory conditions.
• Diagnostic Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) and LC-MS/MS methods for quantifying leukotriene levels in biological samples.
• Academic Research: A vital tool for universities and research institutes exploring cell signaling, mediator biology, and the pathophysiology of chronic inflammatory diseases.
• Pharmaceutical Quality Control: Acts as a system suitability standard and impurity marker in the analysis and quality control of related pharmaceutical compounds.

Basic Information

Product Name	Leukotriene F4
CAS No.	83851-42-7
Molecular Formula	C23H37NO5S
Molecular Weight	439.61 g/mol
Synonyms	LTF4; Leukotriene-F4; 5(S)-Hydroxy-6(R)-(S-cysteinyl)-7,9-trans-11,14-cis-eicosatetraenoic Acid; (5S,6R)-6-[(1R)-1-[[(1S)-1-Carboxy-2-(cysteinyl)ethyl]thio]-1-hydroxyprop-2-en-1-yl]-5-hydroxy-7,9,11,14-icosatetraenoic Acid; 5(S)-Hydroxy-6(R)-(S-cysteinyl)-7,9-trans-11,14-cis-eicosatetraenoate; Cysteinylleukotriene F4
EINECS	Contact for details

Quality Control

Our Leukotriene F4 is produced and handled under strict quality management protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry guidelines for reference standards, and custom purity grades or specific analytical data packages are available to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, cool, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.