Description

Hoocch2O-Peg6-Ch2Cooh CAS NO 83824-29-7 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a carboxylic acid group at each terminus, making it a versatile linker and spacer molecule. This compound is critical for creating stable, water-soluble conjugates in biopharmaceutical development and advanced material science. It is primarily needed by researchers and manufacturers in the pharmaceutical, diagnostics, and nanotechnology sectors for applications such as drug delivery system optimization, surface functionalization, and hydrogel synthesis.

Application

• Bioconjugation and Drug Delivery: Used as a heterobifunctional crosslinker to attach therapeutic agents (e.g., peptides, proteins, small molecules) to carriers like nanoparticles or antibodies, enhancing solubility and circulation time.
• Surface Modification and Functionalization: Employed to introduce carboxylic acid groups onto surfaces (e.g., gold nanoparticles, magnetic beads, sensor chips) for subsequent covalent attachment of biomolecules.
• Hydrogel and Biomaterial Synthesis: Serves as a water-soluble building block or crosslinking agent in the creation of PEG-based hydrogels for tissue engineering and controlled release matrices.
• Diagnostic Reagent Preparation: Facilitates the labeling of antibodies, enzymes, or other probes with tags or solid supports in assay development (e.g., ELISA, lateral flow tests).
• Polymer Chemistry Intermediate: Acts as a macroinitiator or monomer in the synthesis of functional, biodegradable, or stimuli-responsive copolymers.
• Nanotechnology and Micelle Formation: Incorporated into block copolymers to create functionalized micelles or vesicles for targeted delivery applications.

Basic Information

Product Name	Hoocch2O-Peg6-Ch2Cooh
CAS No.	83824-29-7
Molecular Formula	C18H34O11
Molecular Weight	426.46 g/mol
Synonyms	α,ω-Dicarboxy PEG6; 3,6,9,12,15,18-Hexaoxahenicosanedioic acid; PEG 300 diacid; 1,19-Dicarboxy-3,6,9,12,15,18-hexaoxanonadecane; HOOC-PEG6-COOH; Dicarboxy polyethylene glycol (MW ~300); Poly(ethylene glycol) bis(carboxymethyl) ether (n~6); 2,2'-(Ethane-1,2-diylbis(oxy))bis(acetic acid) PEG derivative
EINECS	Contact for details

Quality Control

Our Hoocch2O-Peg6-Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H and ¹³C), HPLC for purity and impurity profiling, and titration for acid value determination, to ensure it meets high-purity standards suitable for research and bioconjugation. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Acid Value	250 - 270 mg KOH/g
Molecular Weight (NMR)	400 - 450 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.