Description

2,5-Piperazinedione,1,4-Dihydroxy-3,6-Dimethyl-(9Ci) is a specialized diketopiperazine derivative, a key structural motif in medicinal chemistry and peptide research. This compound matters for its role as a versatile synthetic intermediate and building block in the development of novel pharmaceuticals and bioactive molecules. It is needed by research scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for applications ranging from drug discovery to advanced material synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of complex drug candidates, particularly those with peptide-like or constrained cyclic structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of protease inhibitors or receptor modulators.
• Peptidomimetic Development: Acts as a scaffold for creating peptidomimetics, which are molecules that mimic peptides but with enhanced stability and bioavailability.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and advanced materials.
• Bioconjugation & Linker Chemistry: Can be utilized in the design of chemical linkers for bioconjugation applications in antibody-drug conjugates (ADCs) or diagnostics.
• Academic & R&D Laboratories: A valuable reagent for investigating new organic reactions and catalytic methodologies involving heterocyclic compounds.

Basic Information

Product Name	2,5-Piperazinedione,1,4-Dihydroxy-3,6-Dimethyl-(9Ci)
CAS No.	83727-16-6
Molecular Formula	C6H10N2O4
Molecular Weight	174.16 g/mol
Synonyms	1,4-Dihydroxy-3,6-dimethylpiperazine-2,5-dione; 3,6-Dimethyl-1,4-dihydroxypiperazine-2,5-dione; 1,4-Dihydroxy-3,6-dimethyl-2,5-piperazinedione; 2,5-Dioxo-1,4-dihydroxy-3,6-dimethylpiperazine; Cyclo(3,6-dimethyl-1,4-dihydroxy-2,5-diketopiperazine); Diketopiperazine derivative, DMHD; (3R,6R)-3,6-Dimethyl-1,4-dihydroxypiperazine-2,5-dione (for stereoisomer)
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,1,4-Dihydroxy-3,6-Dimethyl-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identification (IR, NMR), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.