Description

Valiolamine is a potent and selective α-glucosidase inhibitor, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its primary value lies in its critical role as a building block for the development of anti-diabetic drugs, particularly voglibose, which is used to manage postprandial blood glucose levels. This high-purity intermediate is essential for pharmaceutical R&D laboratories and manufacturers specializing in metabolic disorder therapeutics and enzyme inhibition studies.

Application

• Pharmaceutical Intermediate: Primary building block in the synthesis of the anti-diabetic drug voglibose and related α-glucosidase inhibitors.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic studies targeting carbohydrate metabolism.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry programs focused on metabolic diseases.
• Active Pharmaceutical Ingredient (API) Synthesis: A critical precursor in multi-step GMP manufacturing processes for finished dosage forms.
• Academic Research: Employed in university and institutional labs for studying enzyme kinetics and inhibition mechanisms.

Basic Information

Product Name	Valiolamine
CAS No.	83465-22-9
Molecular Formula	C7H15NO4
Molecular Weight	177.20 g/mol
Synonyms	Valiolamine; (1S,2S,3R,4S,5S)-1-Amino-5-(hydroxymethyl)cyclohexane-1,2,3,4,5-pentol; 1-Amino-1-deoxyvalienol; 1-Deoxy-1-amino-valienol; Valienamine derivative; Voglibose intermediate; AO-128 intermediate
EINECS	Contact for details

Quality Control

Our Valiolamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines and relevant pharmacopeial standards (e.g., USP, EP) for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.