Description

Methylnaltrexone CAS NO 83387-25-1 is a selective peripheral opioid receptor antagonist. This compound is of significant commercial and therapeutic importance as it blocks the undesirable peripheral effects of opioids, such as constipation, without affecting their central analgesic properties. It is primarily required by the pharmaceutical industry for the development and manufacturing of medications designed to treat opioid-induced constipation (OIC) in patients with chronic non-cancer pain or advanced illness.

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of subcutaneous injection formulations.
• Key intermediate in pharmaceutical research focused on peripheral opioid receptor modulation.
• Reference standard for analytical method development and quality control in drug manufacturing.
• Pharmacological research tool for studying the peripheral effects of opioid drugs.
• Development of oral formulations for opioid-induced bowel dysfunction.
• Clinical research material for studies on post-operative ileus.

Basic Information

Product Name	Methylnaltrexone
CAS No.	83387-25-1
Molecular Formula	C21H26NO4
Molecular Weight	356.44 g/mol
Synonyms	Methylnaltrexone Bromide; N-Methylnaltrexone; Relistor (brand name); (R)-N-(cyclopropylmethyl)-noroxymorphone methobromide; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one methobromide; SC-37359; MRZ 2663 BR
EINECS	Contact for details

Quality Control

Our Methylnaltrexone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.