Description

Insulin, Ala(B24)- CAS NO 83381-53-7 is a synthetic insulin analog where the B24 phenylalanine residue is substituted with alanine. This modification is of significant interest in diabetes research for studying the structure-activity relationships of insulin and its interaction with the insulin receptor. It serves as a critical reference standard and intermediate for pharmaceutical R&D, enabling the development of novel therapeutic agents. This high-purity compound is essential for researchers and manufacturers in the fields of endocrinology, metabolic disease studies, and advanced peptide synthesis.

Application

• Pharmaceutical Research & Development: As a key reference standard and intermediate for investigating insulin's mechanism of action and receptor binding affinity.
• Structure-Activity Relationship (SAR) Studies: To understand the impact of specific amino acid substitutions on insulin's biological potency and stability.
• Metabolic Disease Modeling: Used in preclinical studies to explore novel pathways for diabetes treatment and management.
• Biochemical Reagent: Employed in enzymatic assays, receptor binding studies, and other in vitro diagnostic applications.
• Peptide Synthesis Intermediate: Serves as a building block for the chemical synthesis of more complex insulin analogs and conjugates.
• Quality Control & Analytical Standards: Utilized as a certified reference material (CRM) for HPLC, MS, and other analytical methods in QC laboratories.

Basic Information

Product Name	Insulin, Ala(B24)- CAS NO 83381-53-7
CAS No.	83381-53-7
Molecular Formula	C254H377N65O76S6
Molecular Weight	5807.9 g/mol
Synonyms	Ala(B24)-Insulin; [AlaB24]-Insulin; Insulin (Ala-B24); Insulin analog (B24-Ala); B24-Alanine Insulin; Human Insulin Ala(B24) variant; Insulin, B24-Ala; [AlanineB24]Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Ala(B24)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay, related substances, and residual solvents. Specifications can be aligned with pharmacopeial guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 10.0%
Peptide Content	≥ 80.0%
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.