Description

1,2,5-Trimethyl-Piperazine is a versatile, nitrogen-containing heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its value lies in its unique sterically hindered piperazine structure, which is essential for modulating the biological activity and physicochemical properties of target molecules. This intermediate is particularly needed by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty performance chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its piperazine scaffold.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where its structure contributes to efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Modification: Employed as a curing agent or cross-linking modifier in epoxy resin systems and polyurethane formulations.
• Complexing Agent: Utilized in the preparation of metal-organic frameworks (MOFs) and coordination compounds for research and industrial applications.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry research in academic and industrial laboratories.

Basic Information

Product Name	1,2,5-Trimethyl-Piperazine
CAS No.	82546-86-9
Molecular Formula	C7H16N2
Molecular Weight	128.22 g/mol
Synonyms	1,2,5-Trimethylpiperazine; 1,2,5-TMP; 2,3,6-Trimethylpiperazine; Hexahydro-1,2,5-trimethylpyrazine; UNII-9Q8K9S8F8T; NSC 406106; 1,2,5-Trimethyl hexahydropyrazine
EINECS	Contact for details

Quality Control

Our 1,2,5-Trimethyl-Piperazine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) documenting full specifications are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%
Specific Gravity (20°C)	0.88 - 0.92

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.