Description

Epalrestat is a potent and selective aldose reductase inhibitor (ARI) used in the management of diabetic complications. This compound is critical for preventing the accumulation of sorbitol in tissues, which is a key factor in the development of diabetic neuropathy, retinopathy, and nephropathy. It is primarily required by pharmaceutical manufacturers and research institutions developing advanced therapeutic agents for diabetes care.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of medications for diabetic neuropathy.
• Key intermediate in advanced pharmaceutical research for metabolic disorder therapeutics.
• Reference standard in analytical laboratories for quality control and method development.
• Biochemical research tool for studying the polyol pathway and its role in diabetic complications.
• Development of combination therapies targeting oxidative stress in chronic diabetes.

Basic Information

Product Name	Epalrestat
CAS No.	82159-09-9
Molecular Formula	C₁₅H₁₃NO₃S₂
Molecular Weight	319.40 g/mol
Synonyms	Epalrestat; Kinedak; ONO-2235; (E)-3-Carboxymethyl-5-[(2E)-2-methyl-3-phenylpropenylidene]rhodanine; 5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid; (Z)-5-[(2-Methyl-3-phenylpropenylidene)]-4-oxo-2-thioxothiazolidine-3-acetic Acid; (Z)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid
EINECS	Contact for details

Quality Control

Our Epalrestat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.