Description

Magnesium, Chloro[(Trimethylsilyl)Ethynyl]- is a highly reactive organomagnesium reagent, commonly known as (Trimethylsilyl)ethynylmagnesium chloride. This compound is a critical building block in advanced organic synthesis, valued for its ability to introduce the versatile trimethylsilyl-protected acetylene moiety into target molecules. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and efficient carbon-carbon bond formation.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Production: Used in the synthesis of advanced pesticides, herbicides, and plant growth regulators that require acetylene-based functional groups.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent in the creation of specialty polymers, conductive materials, and novel organic frameworks.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, dyes, and liquid crystals where the TMS-acetylene unit is a critical structural component.
• Academic & Industrial R&D: A fundamental tool in methodological development and exploratory chemistry for creating new carbon-carbon bonds.

Basic Information

Product Name	Magnesium, Chloro[(Trimethylsilyl)Ethynyl]-
CAS No.	81952-80-9
Molecular Formula	C5H9ClMgSi
Molecular Weight	144.97 g/mol
Synonyms	(Trimethylsilyl)ethynylmagnesium chloride; Chloro(trimethylsilylethynyl)magnesium; (Trimethylsilyl)acetylene magnesium chloride; TMS-acetylene magnesium chloride; (TMS-ethynyl)magnesium chloride; Magnesium, chloro[(trimethylsilyl)ethynyl]-; 1-Trimethylsilyl-1-magnesioacetylene chloride
EINECS	Contact for details

Quality Control

Our production of (Trimethylsilyl)ethynylmagnesium chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including titration, NMR, and GC analysis. A Certificate of Analysis (COA) detailing purity, concentration (typically supplied as a solution in THF or diethyl ether), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. This compound is highly volatile, easily oxidized, and reacts vigorously with protic solvents and strong acids. It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions to maintain stability and prevent decomposition. Handle and store away from moisture, heat, and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M to 1.0 M in THF or Et2O (Custom concentrations available)
Purity (GC)	≥ 95% (by GC, on solvent-free basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.