Description

(3A,5B,7B,12B)-3,7,12-Trihydroxy-Cholan-24-Oic Acid CAS NO 81938-67-2 is a high-purity, multi-hydroxylated bile acid derivative, a critical intermediate in the synthesis of advanced pharmaceutical compounds. Its precise stereochemistry and functional groups make it an essential building block for developing targeted therapies and diagnostic agents. This compound is primarily required by research institutions and pharmaceutical manufacturers focused on metabolic, hepatic, and gastrointestinal drug discovery.

Application

• Pharmaceutical Intermediate: Key starting material or chiral synthon for the synthesis of novel therapeutic bile acid analogs and hepatoprotective agents.
• Biochemical Research: Used as a reference standard and probe in studies of bile acid metabolism, nuclear receptor (e.g., FXR, TGR5) signaling, and liver function.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs targeting cholestatic liver diseases, gallstones, and metabolic disorders.
• Diagnostic Agent Development: Potential precursor for labeled compounds used in medical imaging and diagnostic assays related to hepatobiliary function.
• Reference Standard: High-purity material for quality control and analytical method development in pharmaceutical manufacturing and regulatory testing.

Basic Information

Product Name	(3A,5B,7B,12B)-3,7,12-Trihydroxy-Cholan-24-Oic Acid
CAS No.	81938-67-2
Molecular Formula	C24H40O5
Molecular Weight	408.57 g/mol
Synonyms	3α,7α,12α-Trihydroxy-5β-cholan-24-oic Acid; Cholic Acid (specifically the 5β,3α,7α,12α isomer); 3,7,12-Trihydroxycholanic Acid; 5β-Cholic Acid; (3α,5β,7α,12α)-3,7,12-Trihydroxycholan-24-oic Acid; 7α,12α-Dihydroxy-3-oxo-5β-cholan-24-oic Acid (related oxidation state); Hyocholic Acid (isomer); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (3A,5B,7B,12B)-3,7,12-Trihydroxy-Cholan-24-Oic Acid is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets exacting research and pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) specifying purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.