Description

14,15-Leukotriene A4 is a specialized leukotriene derivative and a key intermediate in the biosynthesis of pro-inflammatory lipid mediators. This compound is of significant value for biochemical research focused on understanding eicosanoid signaling pathways and inflammatory responses. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers investigating asthma, allergy, and other inflammatory disease mechanisms.

Application

• Biochemical Research: Critical intermediate for studying the lipoxygenase pathway and leukotriene biosynthesis.
• Pharmaceutical Development: Used as a reference standard and synthetic precursor in drug discovery programs targeting inflammatory diseases.
• Academic Studies: Employed in university and institutional labs to investigate cellular signaling and eicosanoid metabolism.
• Diagnostic Reagent Manufacturing: Serves as a key component in the development of enzyme immunoassays (EIAs) and other test kits for leukotriene detection.
• Cell Biology & Immunology: Applied in in vitro studies to modulate inflammatory responses and study receptor interactions.
• Metabolite Analysis: Used as an analytical standard in LC-MS and HPLC methods for the quantification of leukotrienes in biological samples.

Basic Information

Product Name	14,15-Leukotriene A4
CAS No.	81918-96-9
Molecular Formula	C₂₀H₃₀O₃
Molecular Weight	318.45 g/mol
Synonyms	14,15-LTA4; (5Z,7E,9E,14Z)-5,6-Epoxyicosa-7,9,14-trienoic Acid; Leukotriene A4 isomer; 14,15-Epoxy-5,8,10-eicosatrienoic Acid; 14,15-LTA4 Methyl Ester (common derivative); 14,15-Leukotriene A4 Methyl Ester; 14,15-LTA4 Me ester
EINECS	Contact for details

Quality Control

Our 14,15-Leukotriene A4 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is easily oxidized and moisture-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by weight)
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.