Description

2-((3-(4-Acetaminophenoxy)Propyl)Amino)-1,4:3,6-Dianhydro-2-Deoxy-L-Iditol 5-Nitrate HCl H2O is a specialized organic nitrate derivative with a complex molecular architecture, designed for advanced pharmaceutical research and development. This compound is valued for its potential as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of cardiovascular, neurological, or targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly those targeting nitrate-mediated biological pathways.
• Cardiovascular Research: Used in preclinical studies to investigate compounds with potential vasodilatory or anti-anginal properties due to the nitrate ester functional group.
• Neurological Agent Development: Explored for the creation of prodrugs or agents designed to cross the blood-brain barrier, leveraging its specific sugar-derived (dianhydro-deoxy-iditol) backbone.
• Targeted Drug Delivery Systems: The molecular structure may be utilized in the design of conjugates for site-specific drug release.
• Chemical Biology Probes: Acts as a tool compound for studying enzyme interactions or cellular signaling mechanisms involving nitrate metabolism.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of complex active molecules.

Basic Information

Product Name	2-((3-(4-Acetaminophenoxy)Propyl)Amino)-1,4:3,6-Dianhydro-2-Deoxy-L-Iditol 5-Nitrate HCl H2O
CAS No.	81785-52-6
Molecular Formula	C16H24N4O8 • HCl • H2O
Molecular Weight	Contact for details
Synonyms	1,4:3,6-Dianhydro-2-deoxy-2-[[3-(4-acetamidophenoxy)propyl]amino]-L-iditol 5-nitrate hydrochloride hydrate; L-Iditol, 1,4:3,6-dianhydro-2-deoxy-2-[[3-(4-acetamidophenoxy)propyl]amino]-, 5-nitrate, hydrochloride, hydrate; 2-((3-(4-Acetamidophenoxy)propyl)amino)-1,4:3,6-dianhydro-2-deoxy-L-iditol 5-nitrate hydrochloride monohydrate; ISDN-APAP derivative; Isosorbide dinitrate-acetaminophen conjugate HCl salt.
EINECS	Contact for details

Quality Control

Our production of 2-((3-(4-Acetaminophenoxy)Propyl)Amino)-1,4:3,6-Dianhydro-2-Deoxy-L-Iditol 5-Nitrate HCl H2O adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing specifications such as assay, impurity profile, and residual solvents. Our quality systems are designed to support cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under controlled humidity conditions. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.