Description

5-(2-Hydroxy-3-(2-Cyanophenoxy)-Propylamino)-5-Desoxy-1,4:3,6-Dianhydro-L-Iditol 2-Nitrate Hydrochloride is a high-purity, complex organic intermediate with significant potential in advanced pharmaceutical synthesis. This compound matters for its role as a key chiral building block in the development of novel therapeutic agents, particularly those targeting metabolic and cardiovascular pathways. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating new chemical entities and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, especially in metabolic disease and cardiology.
• Biochemical Research: Used as a reference standard or probe in enzymatic studies and receptor binding assays to investigate biological pathways.
• Process Chemistry: Serves as a key starting material or advanced intermediate in the scale-up and optimization of complex, multi-step API (Active Pharmaceutical Ingredient) synthesis.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and stereochemistry.
• Precision Chemical Manufacturing: Utilized in the production of specialized fine chemicals and custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	5-(2-Hydroxy-3-(2-Cyanophenoxy)-Propylamino)-5-Desoxy-1,4:3,6-Dianhydro-L-Iditol 2-Nitrate Hydrochloride
CAS No.	81785-28-6
Molecular Formula	C16H20N4O8 • HCl
Molecular Weight	456.81 g/mol (Free base: 420.35 g/mol)
Synonyms	5-Desoxy-1,4:3,6-dianhydro-5-[2-hydroxy-3-(2-cyanophenoxy)propylamino]-L-iditol 2-nitrate hydrochloride; L-Iditol, 5-deoxy-1,4:3,6-dianhydro-5-[[2-hydroxy-3-(2-cyanophenoxy)propyl]amino]-, 2-nitrate, hydrochloride; Isosorbide 5-(2-Hydroxy-3-(2-cyanophenoxy)propylamino)-5-deoxy-2-nitrate HCl; 5-Desoxyisosorbide-2-nitrate derivative hydrochloride; 81785-28-6; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ rigorous analytical controls including HPLC, chiral analysis, and NMR to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and residual solvents is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.