Description

(-)-3-[2-[(1R,4Aβ)-Decahydro-7β-Hydroxy-5α-Hydroxymethyl-5,8Aα-Dimethyl-2-Methylenenaphthalene-1α-Yl]Ethyl]-2(5H)-Furanone is a high-purity, complex organic intermediate with a defined stereochemistry. This compound is valued for its role as a key chiral building block in advanced synthetic pathways, enabling the production of molecules with specific biological activity. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams working on novel therapeutic agents and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of steroidal or terpenoid-based active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Serves as a chiral starting material or scaffold for constructing complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Used in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Natural Product Synthesis: Employed in the total or semi-synthesis of complex natural products with potential bioactivity.
• Process Chemistry Development: Used to develop and scale up efficient manufacturing routes for target molecules.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	(-)-3-[2-[(1R,4Aβ)-Decahydro-7β-Hydroxy-5α-Hydroxymethyl-5,8Aα-Dimethyl-2-Methylenenaphthalene-1α-Yl]Ethyl]-2(5H)-Furanone
CAS No.	81727-18-6
Molecular Formula	C20H32O4
Molecular Weight	336.47 g/mol
Synonyms	(3R,5aR,7R,8aR)-3-[(1R,4aS,7R,8aR)-7-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,5,6,7,8,8a-octahydro-1H-naphthalen-1-yl]dihydrofuran-2(3H)-one; (1R,4aS,7R,8aR)-1-[2-[(3R,5aR,7R,8aR)-2-Oxo-5a,6,7,8a-tetrahydro-3H-furo[3,4-b][1,4]dioxin-3-yl]ethyl]-7-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,5,6,7,8,8a-octahydro-1H-naphthalene; A key lactone intermediate in forskolin synthesis.
EINECS	Contact for details

Quality Control

Our (-)-3-[2-[(1R,4Aβ)-Decahydro-7β-Hydroxy-5α-Hydroxymethyl-5,8Aα-Dimethyl-2-Methylenenaphthalene-1α-Yl]Ethyl]-2(5H)-Furanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and chemical identity verification, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.