Description

5-Hydroxyeicosatetraenoic Acid Lactone is a specialized eicosanoid lactone derivative, a key intermediate in the study of arachidonic acid metabolism and its biological pathways. This compound is of significant value for advanced biochemical research and pharmaceutical development due to its role as a precursor or analog in inflammatory and signaling cascades. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic agents and analytical standards.

Application

• Biochemical Research: Critical intermediate for studying lipoxygenase pathways, eicosanoid biosynthesis, and related inflammatory mediators.
• Pharmaceutical R&D: Serves as a key building block or reference standard in the development of anti-inflammatory drugs and enzyme inhibitors.
• Analytical Standard: Used as a high-purity certified reference material (CRM) for quantitative analysis in mass spectrometry (LC-MS/MS) and HPLC methods.
• Cell Signaling Studies: Employed in in vitro and in vivo models to investigate the biological effects of hydroxyeicosatetraenoic acid (HETE) metabolites.
• Fine Chemical Synthesis: A valuable chiral synthon for the custom synthesis of more complex bioactive molecules and probes.

Basic Information

Product Name	5-Hydroxyeicosatetraenoic Acid Lactone
CAS No.	81517-87-5
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	5-HETE Lactone; 5-HETE-δ-lactone; 5-Hydroxy-6,8,11,14-eicosatetraenoic acid δ-lactone; (5Z,8Z,11Z,14Z)-5-Hydroxyicosa-6,8,11,14-tetraenoic 1,5-lactone; 5-Hydroxyeicosatetraenoic acid δ-lactone; 5(S)-HETE lactone; 5-HETE-γ-lactone (common misnomer); Leukotriene analog intermediate
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxyeicosatetraenoic Acid Lactone is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including chromatographic purity assays and spectroscopic identification, to meet the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive and should be handled under subdued light. Allow the container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Purity (GC)	≥ 95% (Area %)
Specific Rotation	Contact for details
Water Content (KF)	< 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.