Description

(+/-)11,12-Epoxyeicosa-5Z,8Z,14Z-Trienoic Acid is a specialized epoxy fatty acid derivative of eicosatrienoic acid, serving as a key biochemical intermediate and reference standard. This compound is valued for its role in studying eicosanoid biosynthesis and lipid signaling pathways, particularly those involving cytochrome P450 epoxygenase metabolites. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors for developing novel therapeutic agents and conducting metabolic research.

Application

• Biochemical Research Standard: Used as a high-purity reference compound in lipidomics and eicosanoid research to study the biological activity of epoxy fatty acids.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates targeting inflammation, cardiovascular diseases, and metabolic disorders.
• Cell Signaling Studies: Employed in vitro and in vivo to investigate the role of epoxy-eicosatrienoic acids (EETs) in vascular function, pain perception, and cellular proliferation.
• Enzyme Substrate: Acts as a substrate for studying the activity and inhibition of soluble epoxide hydrolase (sEH), a key therapeutic target.
• Metabolite Analysis: Essential for developing and validating analytical methods (LC-MS, GC-MS) for the quantification of lipid mediators in biological samples.
• Specialty Chemical Synthesis: Used in the production of advanced, biologically active compounds for agrochemical and material science applications.

Basic Information

Product Name	(+/-)11,12-Epoxyeicosa-5Z,8Z,14Z-Trienoic Acid
CAS No.	81276-02-0
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	11,12-EET; 11(12)-Epoxy-5,8,14-eicosatrienoic Acid; (±)11,12-Epoxyeicosatrienoic Acid; 11,12-Epoxyeicosa-5,8,14-trienoic Acid; 11,12-EET Racemate; 11,12-Epoxy-5Z,8Z,14Z-eicosatrienoic Acid; AA861 Epoxy Metabolite; (±)-11,12-EET
EINECS	Contact for details

Quality Control

Our (+/-)11,12-Epoxyeicosa-5Z,8Z,14Z-Trienoic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 97%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.