Description

(+/-)-12-Hydroxy-5Z,8Z,10E,14Z,17Z-Eicosapentaenoic Acid CAS NO 81187-21-5 is a specialized hydroxy fatty acid derivative of eicosapentaenoic acid (EPA), a key ω-3 polyunsaturated fatty acid. This compound serves as a critical biochemical intermediate and reference standard for research into lipid metabolism, inflammation, and specialized pro-resolving mediators (SPMs). It is essential for pharmaceutical R&D, analytical laboratories, and advanced life science research focused on developing novel therapeutics and diagnostic tools.

Application

• Biochemical Research Standard: Used as a high-purity reference material for the identification and quantification of lipid mediators in biological samples via LC-MS/MS and HPLC.
• Pharmaceutical Development: Acts as a key intermediate or active pharmaceutical ingredient (API) precursor in the development of anti-inflammatory and pro-resolving therapeutics.
• Cell Signaling Studies: Employed in vitro and in vivo to study the role of hydroxy-EPA derivatives in cellular signaling pathways related to inflammation resolution.
• Nutritional Science Research: Investigated for its potential bioactive effects as a metabolite of dietary ω-3 fatty acids.
• Analytical Method Development: Serves as a critical standard for developing and validating chromatographic and spectroscopic methods in analytical laboratories.

Basic Information

Product Name	(+/-)-12-Hydroxy-5Z,8Z,10E,14Z,17Z-Eicosapentaenoic Acid
CAS No.	81187-21-5
Molecular Formula	C₂₀H₃₀O₃
Molecular Weight	318.45 g/mol
Synonyms	12-Hydroxy-5Z,8Z,10E,14Z,17Z-eicosapentaenoic acid; 12-HEPE; (±)-12-HEPE; 12-Hydroxy-EPA; 12-Hydroxyeicosapentaenoic acid; 12(S)-HEPE; 12(R)-HEPE (racemic mixture); 5Z,8Z,10E,14Z,17Z-12-Hydroxyeicosapentaenoic Acid
EINECS	Contact for details

Quality Control

Our (+/-)-12-Hydroxy-5Z,8Z,10E,14Z,17Z-Eicosapentaenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0% (Area Percent)
Purity (GC)	≥ 90.0%
Solubility	Soluble in ethanol, DMSO, methanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.