Description

Phorbol 12-n-Methylanthranilate is a specialized phorbol ester derivative, a class of compounds known for their potent biological activity. This high-purity reference standard is critical for pharmaceutical research, particularly in the study of protein kinase C (PKC) signaling pathways and tumor promotion mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) engaged in oncology, toxicology, and biochemical assay development.

Application

• Biochemical Research: As a potent activator of Protein Kinase C (PKC) isoforms for studying cell signaling, proliferation, and differentiation.
• Oncology Studies: Used as a tumor-promoting agent in experimental models to investigate carcinogenesis and evaluate potential chemopreventive compounds.
• Pharmacology & Toxicology: Serves as a key reference standard in assays designed to understand drug mechanisms and assess compound toxicity related to PKC modulation.
• Assay Development: Employed in the standardization and validation of high-throughput screening (HTS) assays within drug discovery pipelines.
• Academic Research: A vital tool in university laboratories for fundamental research in cell biology, molecular biology, and signal transduction.

Basic Information

Product Name	Phorbol 12-n-Methylanthranilate
CAS No.	80998-07-8
Molecular Formula	C36H43NO7
Molecular Weight	601.73 g/mol
Synonyms	12-O-n-Methylanthraniloylphorbol-13-acetate; PMA analog; 12-O-Methylanthraniloylphorbol-13-acetate; 12-n-Methylanthraniloylphorbol-13-acetate; TPA Methylanthranilate; Phorbol 12-Methylanthranilate 13-Acetate; 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 12-(2-methylaminobenzoate) 13-acetate
EINECS	Contact for details

Quality Control

Our Phorbol 12-n-Methylanthranilate is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.