Description

Aztreonam CAS NO 80951-91-3 is a synthetic monobactam antibiotic belonging to the β-lactam class. This compound is critically important for its potent and specific activity against aerobic Gram-negative bacteria, including Pseudomonas aeruginosa. It is primarily utilized in the pharmaceutical industry for the research, development, and manufacturing of sterile injectable formulations to treat serious systemic infections, offering a valuable therapeutic option where penicillin or cephalosporin allergies are a concern.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of sterile injectable antibiotic formulations.
• Clinical Research & Development: Used in studies for novel combination therapies against multidrug-resistant Gram-negative pathogens.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and microbiological assays.
• Veterinary Medicine: Applied in the development of treatments for bacterial infections in animals.
• Microbiological Studies: Essential tool for in-vitro susceptibility testing and mechanism of action research.

Basic Information

Product Name	Aztreonam
CAS No.	80951-91-3
Molecular Formula	C13H17N5O8S2
Molecular Weight	435.43 g/mol
Synonyms	Azactam; SQ 26,776; (Z)-2-[[[(2-Amino-4-thiazolyl)[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]carbamoyl]methylene]amino]oxy]-2-methylpropionic acid; Monobactam antibiotic; Azthreonam; Azreonam; 3-(((Z)-((2-Amino-4-thiazolyl)(((2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2,2-dimethylpropanoic acid
EINECS	Contact for details

Quality Control

Our Aztreonam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and stringent control of impurities and residual solvents to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) with detailed batch-specific results are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	-55° to -65° (c=1 in water)
pH (1% solution)	4.5 - 7.5
Bacterial Endotoxins	< 0.17 EU/mg (where applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.