Description

(1B,3A,5B,7A,12A)-1,3,7,12-Tetrahydroxy-Cholan-24-Oic Acid is a high-purity, multi-hydroxylated bile acid derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its precise stereochemistry and functional group array make it a critical building block for research and production in medicinal chemistry. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical and biotechnology sectors developing novel therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex steroid-based drugs and therapeutic bile acids.
• Biochemical Research: Used as a reference standard and substrate in metabolic pathway studies, particularly those involving cholesterol and bile acid metabolism.
• API Synthesis: Serves as a key chiral starting material for the production of Active Pharmaceutical Ingredients (APIs) with specific hydroxylation patterns.
• Diagnostic Reagent Development: Employed in the formulation of calibrators and controls for clinical diagnostic assays targeting liver function and metabolic disorders.
• Cell Culture & Media Supplement: Investigated for use in specialized cell culture media to influence cell signaling and membrane fluidity.
• Chemical Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in regulatory environments.

Basic Information

Product Name	(1B,3A,5B,7A,12A)-1,3,7,12-Tetrahydroxy-Cholan-24-Oic Acid
CAS No.	80875-94-1
Molecular Formula	C24H40O6
Molecular Weight	424.57 g/mol
Synonyms	1,3,7,12-Tetrahydroxycholan-24-oic Acid; 1β,3α,7α,12α-Tetrahydroxy-5β-cholan-24-oic Acid; 5β-Cholan-24-oic acid-1β,3α,7α,12α-tetrol; Tetrahydroxycholanic Acid; 1,3,7,12-Tetrahydroxy-5β-cholan-24-oic Acid; 1,3,7,12-Tetrahydroxy-5β-cholanoic Acid
EINECS	Contact for details

Quality Control

Our (1B,3A,5B,7A,12A)-1,3,7,12-Tetrahydroxy-Cholan-24-Oic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.