Description

[R,(+)]-1-O,2-o-Dipalmitoyl-L-Glycerol 3-(Phosphoric Acid Dibenzyl) Ester is a high-purity, enantiomerically pure synthetic phospholipid derivative, specifically a phosphoglyceride with a dibenzyl-protected phosphate group. This compound is a critical advanced intermediate in the synthesis of complex bioactive lipids and phospholipids, offering researchers precise control over stereochemistry and molecular structure. It is primarily utilized by pharmaceutical R&D teams, academic research laboratories, and manufacturers of liposomal drug delivery systems and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel phospholipid-based active pharmaceutical ingredients (APIs) and prodrugs.
• Lipid Nanoparticle (LNP) & Liposome Research: Used in the development and formulation of next-generation drug delivery vehicles for mRNA, siRNA, and other therapeutic cargo.
• Biochemical Research: Serves as a substrate or precursor in enzymatic studies and for investigating lipid metabolism and signaling pathways.
• Synthetic Chemistry: A versatile chiral synthon for constructing complex, stereodefined natural products and membrane components.
• Diagnostic Agent Development: Potential use in creating targeted contrast agents or probes for medical imaging.
• Excipient & Formulation Science: Research into novel lipid excipients to enhance drug solubility, stability, and bioavailability.

Basic Information

Product Name	[R,(+)]-1-O,2-o-Dipalmitoyl-L-Glycerol 3-(Phosphoric Acid Dibenzyl) Ester
CAS No.	80795-00-2
Molecular Formula	C51H85O9P
Molecular Weight	873.19 g/mol
Synonyms	1,2-Dipalmitoyl-sn-glycerol-3-phosphoric Acid Dibenzyl Ester; (R)-1,2-Dihexadecanoyl-3-(dibenzylphosphatidyl)glycerol; sn-Glycerol 1,2-dipalmitate 3-(dibenzyl phosphate); Dibenzyl 1,2-dipalmitoyl-sn-glycero-3-phosphate; Dipalmitoyl Phosphatidic Acid Dibenzyl Ester; L-α-Dipalmitoylphosphatidic Acid Dibenzyl Ester; PA(Dipalmitoyl) Dibenzyl Ester; PG Precursor (Dibenzyl Protected)
EINECS	Contact for details

Quality Control

Our production of this advanced lipid intermediate adheres to stringent GMP-grade principles for research chemicals. Every batch is characterized using advanced analytical techniques to ensure high enantiomeric purity and chemical identity. Comprehensive Certificates of Analysis (COA) are provided, detailing specifications for purity, identity, and critical impurities. We support cGMP compliance for investigational applications with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep the material in its original container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% [R,(+)]
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.