Description

o-Formylmandeloyl Chloride is a versatile and highly reactive acid chloride derivative used as a key building block in advanced organic synthesis. Its primary value lies in its bifunctional nature, containing both an acid chloride and a formyl group, which allows for selective and sequential reactions to construct complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and specialized agrochemical intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, especially those requiring mandelic acid or benzaldehyde derivative scaffolds.
• Peptide Mimetics & Prodrug Synthesis: Used to introduce formyl-protected mandelate groups, which can be further modified to create targeted drug delivery systems.
• Agrochemical Active Ingredients: Serves as a building block for novel herbicides, fungicides, and plant growth regulators.
• Chiral Auxiliary & Resolving Agent Precursor: The mandelic acid core provides a chiral center useful for asymmetric synthesis and the preparation of chiral ligands.
• Polymer & Specialty Chemical Monomer: Can be polymerized or incorporated into polymers to impart specific functional properties.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	o-Formylmandeloyl Chloride
CAS No.	80543-51-7
Molecular Formula	C9H7ClO3
Molecular Weight	198.60 g/mol
Synonyms	2-Formyl-2-phenylacetyl chloride; (2-Formyl-2-phenylethanoyl) chloride; α-Formylbenzeneacetyl chloride; Mandelic acid, o-formyl-, chloride; o-Formylmandelic acid chloride; Phenylglyoxylic acid, O-(chloroformyl)-; Benzeneacetic acid, α-formyl-, chloride (9CI)
EINECS	Contact for details

Quality Control

Our o-Formylmandeloyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed and allowed to reach ambient temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.