Description

4-(Piperazin-1-Yl)-Benzoic Acid Ethyl Ester is a versatile and high-value pharmaceutical intermediate characterized by its benzoic acid ester core linked to a piperazine moiety. This molecular architecture makes it a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted receptor modulation. It is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries seeking reliable, high-purity intermediates for drug discovery and scale-up.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and cardiovascular diseases.
• Chemical Synthesis Building Block: Used in organic synthesis to introduce the 4-(piperazin-1-yl)benzoate functional group, enabling the creation of libraries of compounds for high-throughput screening.
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial research labs for medicinal chemistry and process chemistry studies.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the commercial-scale production of specific APIs where its structural motif is integral to biological activity.
• Ligand and Probe Development: Useful in the development of biochemical probes and receptor ligands due to the piperazine group's ability to act as a hydrogen bond acceptor and donor.

Basic Information

Product Name	4-(Piperazin-1-Yl)-Benzoic Acid Ethyl Ester
CAS No.	80518-57-6
Molecular Formula	C13H18N2O2
Molecular Weight	234.30 g/mol
Synonyms	Ethyl 4-(piperazin-1-yl)benzoate; 4-Piperazin-1-yl-benzoic acid ethyl ester; Benzoic acid, 4-(1-piperazinyl)-, ethyl ester; Ethyl 4-piperazin-1-ylbenzoate; 1-[4-(Ethoxycarbonyl)phenyl]piperazine; Ethyl p-(piperazin-1-yl)benzoate; 4-(1-Piperazinyl)benzoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our 4-(Piperazin-1-Yl)-Benzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.