Description

Methoxypolyethylene Glycol Amine is a bifunctional polymer derivative featuring a terminal methoxy group and a reactive primary amine group. This unique structure makes it a highly versatile intermediate for creating functionalized polymers and conjugates with tailored properties. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors who require precise surface modification and controlled chemical linkage. The compound is commercially available under various molecular weight ranges to suit specific application needs.

Application

• Pharmaceutical PEGylation: Conjugation to peptides, proteins, and oligonucleotides to enhance solubility, stability, and circulation half-life.
• Bioconjugation & Cross-linking: Acting as a heterobifunctional linker for attaching dyes, drugs, or other molecules to biomolecules and surfaces.
• Surface Functionalization: Modification of nanoparticles, quantum dots, and solid supports to introduce amine-reactive sites for further coupling.
• Polymer Synthesis: Used as a macroinitiator or monomer in the synthesis of block copolymers and functional hydrogels.
• Diagnostic Reagents: Preparation of labeled antibodies and assay components for improved performance in diagnostic kits.
• Cosmetic & Personal Care: As a conditioning agent and emulsifier in advanced formulations requiring mild, skin-friendly polymers.

Basic Information

Product Name	Methoxypolyethylene Glycol Amine
CAS No.	80506-64-5
Molecular Formula	CH3O(CH2CH2O)nCH2CH2NH2 (n varies)
Molecular Weight	Variable (typically 350 - 40,000 Da). Contact for details on specific grades.
Synonyms	mPEG-Amine; mPEG-NH2; Methoxy PEG Amine; Poly(ethylene glycol) methyl ether amine; α-Methoxy-ω-amino poly(ethylene glycol); O-Methylpolyethylene glycol amine; PEG methyl ether amine; Amine-terminated mPEG; mPEG-NH2
EINECS	Contact for details

Quality Control

Our Methoxypolyethylene Glycol Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and low levels of diol and aldehyde impurities. Certificates of Analysis (COA) are provided with every shipment, detailing specifications for assay, polydispersity index (PDI), and functional group content. We support cGMP manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Under these conditions, the product is typically stable for at least 24 months from the date of receipt.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Amino Content)	≥ 95% (or as per grade)
Molecular Weight (Mn)	As per ordered grade (e.g., 2000, 5000 Da)
Polydispersity Index (PDI)	≤ 1.05 (for low PDI grades)
Purity (HPLC)	≥ 98.0%
Moisture (KF)	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.