Description

Leukotriene B5 CAS NO 80445-66-5 is a specialized eicosanoid metabolite derived from eicosapentaenoic acid (EPA), playing a significant role as a potent lipid mediator in inflammatory and immune response pathways. Its distinct structure from the more common LTB4 makes it a critical compound for advanced biochemical research and pharmaceutical development. This high-purity reference standard is essential for researchers and manufacturers in the fields of immunology, pharmacology, and analytical chemistry.

Application

• Biochemical Research Standard: Used as a high-purity reference material in studies of leukotriene biosynthesis, metabolism, and receptor interactions.
• Inflammation & Immunology Studies: A key tool for investigating the specific roles of EPA-derived mediators in inflammatory processes and immune cell signaling.
• Pharmaceutical R&D: Serves as a critical standard in the development and validation of assays for novel anti-inflammatory drug candidates targeting the 5-lipoxygenase pathway.
• Analytical Method Development: Employed as a calibration standard in advanced analytical techniques such as LC-MS/MS and HPLC for the quantification of eicosanoids in biological samples.
• Metabolomics & Lipidomics: An important analyte in profiling lipid mediators to understand disease mechanisms related to ω-3 fatty acid metabolism.

Basic Information

Product Name	Leukotriene B5
CAS No.	80445-66-5
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.5 g/mol
Synonyms	LTB5; (5S,12R)-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic Acid; 5(S),12(R)-Dihydroxy-6,8,10,14-eicosatetraenoic Acid; (5S,12R)-Dihydroxyicosa-6,8,10,14-tetraenoic Acid; EPA-derived Leukotriene B; ω-3 Leukotriene
EINECS	Contact for details

Quality Control

Our Leukotriene B5 is produced under stringent quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques like HPLC and mass spectrometry to verify product integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is easily oxidized and light-sensitive; allow it to reach room temperature in a desiccator before opening to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.