Description

1,4-Bis((2-Methyl-5-Nitro-1H-Imidazol-1-Yl)Acetyl)Piperazine is a specialized heterocyclic compound featuring a piperazine core symmetrically functionalized with nitroimidazole-acetyl groups. This unique molecular architecture makes it a valuable high-purity intermediate for advanced pharmaceutical research and synthesis. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly in areas requiring complex, multi-functional building blocks.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting anaerobic bacteria and protozoa.
• Antiprotozoal Agent Research: Used in the research and development of next-generation nitroimidazole-based drugs for treating infections like giardiasis and trichomoniasis.
• Antibacterial Drug Development: Acts as a key building block for creating new antibacterial compounds, leveraging the bioactive nitroimidazole moiety.
• Bioconjugation and Prodrug Synthesis: Utilized in designing prodrugs or antibody-drug conjugates (ADCs) where its functional groups allow for specific linkage chemistry.
• Chemical Biology Probes: Employed in developing molecular probes to study enzyme mechanisms or cellular pathways involving nitroreductase activity.
• Fine Chemical Synthesis: Functions as a versatile intermediate for constructing more complex heterocyclic systems in medicinal chemistry.

Basic Information

Product Name	1,4-Bis((2-Methyl-5-Nitro-1H-Imidazol-1-Yl)Acetyl)Piperazine
CAS No.	80348-51-2
Molecular Formula	C20H22N8O6
Molecular Weight	470.44 g/mol
Synonyms	1,4-Bis(2-methyl-5-nitro-1H-imidazol-1-yl)-2-oxoethylpiperazine; Piperazine, 1,4-bis[(2-methyl-5-nitro-1H-imidazol-1-yl)acetyl]-; 1,4-Bis[(2-methyl-5-nitroimidazol-1-yl)acetyl]piperazine; 1,4-Bis(1-acetyl-2-methyl-5-nitroimidazolyl)piperazine; NSC 339586; Symmetrical Nitroimidazole-Piperazine Derivative; Bis-nitroimidazole acetylpiperazine
EINECS	Contact for details

Quality Control

Our 1,4-Bis((2-Methyl-5-Nitro-1H-Imidazol-1-Yl)Acetyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.