Description

3-Chloro-4-Fluorobenzoyl Fluoride is a high-purity, reactive aromatic intermediate featuring both chloro and fluoro substituents on the benzene ring, activated by a highly electrophilic acyl fluoride group. This compound matters as a critical building block for synthesizing advanced agrochemicals and pharmaceuticals, where its unique halogen pattern enables precise molecular design. It is primarily needed by R&D chemists and process development teams in the fine chemical, agrochemical, and pharmaceutical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated aromatic cores in electronic chemicals for displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce halogenated benzoyl groups into polymer chains, altering thermal and chemical resistance properties.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Peptide Mimetic & Protease Inhibitor Research: Used in medicinal chemistry to develop protease inhibitors and other peptide-based therapeutics.

Basic Information

Product Name	3-Chloro-4-Fluorobenzoyl Fluoride
CAS No.	80277-51-6
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	3-Chloro-4-fluorobenzoic acid fluoride; 4-Fluoro-3-chlorobenzoyl fluoride; 3-Chloro-4-fluorobenzoic acid, fluoride; 3-Chloro-4-fluorobenzoyl fluoride; Benzoic acid, 3-chloro-4-fluoro-, fluoride; 80277-51-6; 3-Chlor-4-fluorbenzoylfluorid (German)
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorobenzoyl Fluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with strong acids and organic solvents; ensure the container is kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.