Description

Nafamostat (Hydrochloride) CAS NO 80251-32-7 is a potent synthetic serine protease inhibitor with significant anticoagulant and anti-inflammatory properties. This compound is critical for research and development in the pharmaceutical and life sciences sectors, where precise biochemical modulation is required. It is primarily utilized by researchers and manufacturers focused on developing treatments for pancreatitis, disseminated intravascular coagulation (DIC), and as an anticoagulant in extracorporeal circulation procedures.

Application

• Pharmaceutical Research & Development: Key intermediate or active ingredient in the development of novel therapeutics for acute pancreatitis and other inflammatory conditions.
• Anticoagulant Agent: Used in clinical settings and research as a potent, short-acting anticoagulant, particularly in hemodialysis and extracorporeal membrane oxygenation (ECMO) circuits.
• Protease Inhibition Studies: A vital tool compound in biochemical and pharmacological research to study the mechanisms of serine proteases like trypsin, kallikrein, and thrombin.
• Inflammation & Immunology Research: Investigated for its potential to modulate inflammatory pathways and immune responses in various disease models.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	Nafamostat (Hydrochloride)
CAS No.	80251-32-7
Molecular Formula	C19H17N5O2 • HCl
Molecular Weight	399.83 g/mol
Synonyms	Nafamostat Hydrochloride; Nafamostat Mesilate Impurity C (HCl); 6-Amidino-2-naphthyl 4-guanidinobenzoate Hydrochloride; FUT-187; Futhan; 4-Guanidinobenzoic Acid 6-Amidino-2-naphthyl Ester Hydrochloride; (6-Amidino-2-naphthyl) 4-guanidinobenzoate Hydrochloride
EINECS	Contact for details

Quality Control

Our Nafamostat Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support its use in research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to meet the stringent requirements of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.