Description

(8R,15S)-Dihydroxy-(5Z,9E,11Z,13E)-Eicosatetraenoic Acid is a specialized dihydroxy fatty acid derivative, specifically a dihydroxyeicosatetraenoic acid (diHETE) regioisomer, that serves as a critical bioactive lipid mediator in mammalian systems. This compound matters for its role in modulating inflammatory and immune responses, making it a valuable reference standard and research tool for studying eicosanoid signaling pathways. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, biochemical research, and analytical method development.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in LC-MS, HPLC, and GC-MS for the identification and quantification of eicosanoid metabolites in biological samples.
• Inflammation & Immunology Studies: A key tool for investigating the role of specific lipoxygenase (LOX) pathway metabolites in cellular signaling, inflammation resolution, and immune cell function.
• Pharmaceutical R&D: Serves as a critical intermediate or target molecule in the development of novel therapeutics aimed at modulating inflammatory diseases, such as asthma, arthritis, and dermatitis.
• Enzyme Activity Assays: Employed as a substrate or product in assays to study the activity and inhibition of enzymes like 15-lipoxygenase and related metabolic pathways.
• Cell Culture & In Vitro Models: Applied in cell-based assays to study the effects of specific diHETEs on cell proliferation, differentiation, and apoptosis.
• Metabolomics & Lipidomics: An essential component in targeted metabolomic profiling to map lipid mediator networks and understand disease mechanisms.

Basic Information

Product Name	(8R,15S)-Dihydroxy-(5Z,9E,11Z,13E)-Eicosatetraenoic Acid
CAS No.	80234-64-6
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	(8R,15S)-diHETE; 8(R),15(S)-Dihydroxy-5Z,9E,11Z,13E-eicosatetraenoic Acid; 8,15-DiHETE; 8(R),15(S)-DiHETE; 5Z,9E,11Z,13E-8,15-DiHETE; (8R,15S)-DiHETE; 8,15-Lipoxygenase Metabolite; Leukotriene B4 Isomer
EINECS	Contact for details

Quality Control

Our (8R,15S)-Dihydroxy-(5Z,9E,11Z,13E)-Eicosatetraenoic Acid is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, isomeric purity, and potency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area designated for laboratory chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity	≥ 98% (by chiral analysis)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.