Description

Gonyautoxin Viii is a potent neurotoxin belonging to the saxitoxin family, a group of naturally occurring compounds known for their high biological activity. This compound is of significant interest for advanced scientific research and analytical applications due to its specific mechanism of action on voltage-gated sodium channels. It is primarily utilized by researchers in toxicology, marine biology, and pharmacology, as well as by laboratories developing detection methods for marine biotoxins.

Application

• Reference Standard for Toxin Analysis: Serves as a critical certified reference material (CRM) for the accurate quantification of paralytic shellfish poisoning (PSP) toxins in seafood safety monitoring programs.
• Pharmacological Research: Used as a highly selective molecular tool to study the structure and function of voltage-gated sodium channels in neuronal and cardiac tissues.
• Toxicology Studies: Employed in bioassays and in vitro studies to investigate the mechanisms of neurotoxicity and to evaluate potential antidotes.
• Method Development and Validation: Essential for developing and calibrating advanced analytical techniques such as Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for environmental and food safety testing.
• Marine Biotoxin Research: Key compound for studying the biosynthesis, ecology, and impact of harmful algal blooms (HABs) produced by dinoflagellates.

Basic Information

Product Name	Gonyautoxin Viii
CAS No.	80226-62-6
Molecular Formula	C10H17N7O7
Molecular Weight	323.29 g/mol
Synonyms	GTX8; Gonyautoxin-8; 11-Hydroxysaxitoxin; 11-Hydroxy-STX; (3aS,4R,9aS)-2,6-Diamino-4-(((aminocarbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-1H,10H-pyrrolo[1,2-c]purine-9,9,10-triol; 11-Hydroxysaxitoxin 4-sulfate; Paralytic Shellfish Poison GTX8
EINECS	Contact for details

Quality Control

Our Gonyautoxin Viii is produced and handled under strict quality protocols suitable for research and analytical use. Each batch is characterized using advanced spectroscopic and chromatographic methods to ensure identity and purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, purity, and related substances is provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 90% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.