Description

Microcystin Ll CAS NO 154037-67-9 is a potent cyclic heptapeptide hepatotoxin produced by certain freshwater cyanobacteria. This compound is of critical importance for environmental monitoring, toxicological research, and the development of detection methods for cyanobacterial blooms. It serves as a vital reference standard and research material for analytical laboratories, regulatory agencies, and academic institutions focused on water safety and toxin analysis.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for the calibration and validation of analytical methods, including LC-MS/MS and ELISA, for microcystin detection in water samples.
• Toxicological Research: Essential for studying the mechanisms of hepatotoxicity, including the inhibition of protein phosphatases 1 and 2A, and for assessing the chronic health risks associated with cyanotoxin exposure.
• Environmental Monitoring: Used to develop and quality-control testing protocols for monitoring cyanobacterial blooms in drinking water reservoirs, recreational waters, and aquaculture facilities.
• Method Development & Validation: Critical for laboratories developing new, more sensitive, or standardized detection techniques to comply with global water quality guidelines.
• Diagnostic Kit Production: Serves as a key antigen in the production and calibration of immunoassay-based test kits for rapid on-site screening of water toxins.
• Regulatory Compliance & Proficiency Testing: Used by accredited testing laboratories to demonstrate competency and ensure compliance with national and international water safety standards (e.g., WHO, EPA).

Basic Information

Product Name	Microcystin Ll
CAS No.	154037-67-9
Molecular Formula	C49H74N10O12
Molecular Weight	995.2 g/mol
Synonyms	Microcystin-LA; [D-Asp3, Dha7]Microcystin-LR; Cyanoginosin LA; MC-LA; Microcystin variant LA; (all-*S*)-3-Amino-12-[(2*S*)-2-[[(2*S*,4*E*)-2-[[(4*S*)-4-[[(2*S*)-5-Amino-1-[[(2*S*)-1-[[(4*S*)-4-[[(2*S*)-2-[[(2*S*)-2-[[(2*S*,3*S*)-2-[[(2*S*)-2-[[(2*S*)-2-Amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-5-oxo-5-[(phenylmethyl)amino]pentanoyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopent-4-en-2-yl]amino]-2-oxoethyl]amino]-2-butenoyl]amino]-9-methoxy-2,6,10-trimethyl-4,7,11-trioxo-1-oxa-5,8-diazacyclododec-9-ene-12-carboxylic acid
EINECS	Contact for details

Quality Control

Our Microcystin Ll is produced and handled under strict quality-controlled conditions to ensure the highest purity and stability for research and analytical applications. Each batch is characterized using advanced analytical techniques, including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS), to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chromatographic data, and storage recommendations is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 5.0 %
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.