Description

7-Desmethylmicrocystin Rr is a naturally occurring cyclic heptapeptide toxin structurally related to microcystin-LR, distinguished by the absence of a methyl group at the 7-position of the Adda side chain. It serves as a critical analytical reference standard for environmental monitoring, toxicological research, and method validation in water safety and cyanotoxin detection programs. This compound is essential for laboratories conducting regulatory compliance testing (e.g., WHO, EPA, EU Drinking Water Directive), academic studies on hepatotoxic mechanisms, and development of immunoassays or LC-MS/MS quantification protocols. Researchers and quality control labs in public health agencies, contract testing facilities, and pharmaceutical R&D centers rely on its high chemical fidelity and batch-to-batch consistency.

Application

• Primary reference standard for quantitative LC-MS/MS and HPLC-UV analysis of microcystin variants in drinking water, surface water, and algal bloom samples
• Calibration material for EPA Method 544 and ISO/IEC 17025-accredited cyanotoxin testing laboratories
• Positive control in ELISA and lateral flow immunoassay development for rapid field detection of microcystins
• Mechanistic toxicology studies investigating structure–activity relationships (SAR) of protein phosphatase 1 and 2A inhibition
• Reference material for validating sample extraction efficiency and matrix interference correction in complex environmental matrices
• Quality assurance tool in certified reference material (CRM) production for interlaboratory comparison studies
• Training standard for laboratory personnel in cyanotoxin handling, risk assessment, and analytical method transfer

Basic Information

Product Name	7-Desmethylmicrocystin Rr
CAS No.	131022-02-1
Molecular Formula	C46H72N10O12
Molecular Weight	913.12 g/mol
Synonyms	7-Desmethyl-MC-RR; Desmethylmicrocystin RR; [D-Asp3]Microcystin-RR; MC-RR (7-desmethyl); N-(1-carboxyethyl)-L-leucine derivative of microcystin-RR; Cyclo(-D-Asp-L-Arg-D-MeAsp-L-Leu-D-MeAsp-L-Arg-Adda-D-Glu-Mdha-); 7-Desmethylmicrocystin RR; Desmethyl-MCRR
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (IR, HPLC retention time match), purity (≥95.0% by HPLC-UV), and structural integrity (NMR and HRMS confirmation). Testing follows ISO/IEC 17025 guidelines, and manufacturing adheres to cGMP principles for reference standards. Traceability to primary standards and full impurity profiling (including related microcystins and degradation products) are provided in the COA.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain in a low-humidity environment (<30% RH) with desiccant. Avoid repeated freeze-thaw cycles. Allow vial to equilibrate to room temperature in a desiccator before opening.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Identification (IR)	Characteristic amide I and II bands; matches reference spectrum
Assay (HPLC-UV)	≥95.0%
Related Substances (HPLC)	Each impurity ≤1.0%; total impurities ≤3.0%
Water Content (Karl Fischer)	≤5.0%
Residue on Ignition	≤0.1%
Solubility	Soluble in methanol, acetonitrile, and aqueous acetic acid (0.1%); sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.