Description

Ethyl n-Cbz-4-Piperidineacetate is a protected amino acid ester derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile piperidine scaffold with orthogonal protecting groups, enabling the controlled construction of complex nitrogen-containing molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing active pharmaceutical ingredients (APIs), fine chemicals, and novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of piperidine-based drug candidates, including potential analgesics, CNS agents, and receptor modulators.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate constrained amino acid analogs into peptide chains to enhance stability, bioavailability, and biological activity.
• Agrochemical Research: Serves as a building block for developing novel pesticides and herbicides that utilize the piperidine pharmacophore.
• Academic & Contract Research: Employed in medicinal chemistry programs for library synthesis and structure-activity relationship (SAR) studies of nitrogen heterocycles.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals, catalysts, and ligands for asymmetric synthesis.

Basic Information

Product Name	Ethyl n-Cbz-4-Piperidineacetate
CAS No.	80221-26-7
Molecular Formula	C17H23NO4
Molecular Weight	305.37 g/mol
Synonyms	Ethyl 2-[(phenylmethoxy)carbonyl]amino]-4-piperidineacetate; Ethyl 1-Cbz-4-piperidineacetate; Ethyl N-Carbobenzoxy-4-piperidineacetate; Ethyl (4-Piperidinyl)acetate, N-Cbz derivative; 1-[(Benzyloxy)carbonyl]-4-piperidineacetic Acid Ethyl Ester; N-Cbz-4-Piperidineacetic Acid Ethyl Ester; 80221-26-7
EINECS	Contact for details

Quality Control

Our Ethyl n-Cbz-4-Piperidineacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.