Description

Diethyl (Difluoro(Trimethylsilyl)Methyl) -Phosphonate, 96 is a high-purity, organosilicon-containing phosphonate reagent that serves as a versatile building block in advanced synthetic chemistry. Its unique structure, featuring both difluoromethylene and trimethylsilyl groups, makes it a critical precursor for introducing fluorinated and silylated motifs into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, enabling the synthesis of novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides with enhanced metabolic stability and bioavailability.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers, liquid crystals, and surface-modifying agents.
• Organofluorine Chemistry: Acts as a difluoromethylene (CF2) transfer reagent in nucleophilic and radical addition reactions.
• Cross-Coupling Reactions: Utilized in Horner-Wadsworth-Emmons (HWE) olefination and other carbon-carbon bond-forming processes.
• Silyl Group Transfer: Serves as a source of the trimethylsilyl (TMS) group in protective group chemistry and functional group transformations.

Basic Information

Product Name	Diethyl (Difluoro(Trimethylsilyl)Methyl) -Phosphonate, 96
CAS No.	80077-72-1
Molecular Formula	C8H19F2O3PSi
Molecular Weight	260.29 g/mol
Synonyms	Diethyl (Difluoro(Trimethylsilyl)Methyl)Phosphonate; (Difluoro(Trimethylsilyl)Methyl)Phosphonic Acid Diethyl Ester; Diethyl [(Difluoro)(Trimethylsilyl)Methyl]Phosphonate; (Trimethylsilyl)Difluoromethylphosphonic Acid Diethyl Ester; TMS-CF2-P(O)(OEt)2; Diethyl (Trimethylsilyl)Difluoromethylphosphonate; (Difluorotrimethylsilylmethyl)Phosphonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl (Difluoro(Trimethylsilyl)Methyl) -Phosphonate, 96 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ³¹P), GC, and HPLC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.