Description

D-Isosorbide Dinitrate is a high-purity organic nitrate compound, recognized for its critical role as a key pharmaceutical intermediate. Its primary commercial value lies in its conversion into active pharmaceutical ingredients (APIs) for cardiovascular therapeutics. This product is essential for manufacturers in the pharmaceutical industry, particularly those developing and producing vasodilator medications for angina pectoris and heart failure management.

Application

• Pharmaceutical Intermediate: The primary application is as a precursor in the synthesis of Isosorbide Mononitrate, a major anti-anginal drug.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the controlled manufacturing of nitrate-based vasodilator APIs for cardiovascular treatments.
• Research & Development: Serves as a critical reference standard and starting material in pharmaceutical R&D for new cardiovascular drug formulations.
• Controlled-Release Formulations: Employed in the development of extended-release dosage forms to ensure stable and prolonged therapeutic effects.

Basic Information

Product Name	D-Isosorbide Dinitrate
CAS No.	8063-88-5
Molecular Formula	C6H8N2O8
Molecular Weight	236.14 g/mol
Synonyms	1,4:3,6-Dianhydro-D-glucitol 2,5-dinitrate; Isosorbide Dinitrate; D-ISDN; (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate; Sorbide Nitrate; Sorbidinitrat; D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
EINECS	Contact for details

Quality Control

Our D-Isosorbide Dinitrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, containers should be opaque or kept in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.