Description

Curare CAS NO 8063-06-7 is a complex mixture of alkaloids historically sourced from specific South American plants, primarily known for its potent neuromuscular blocking properties. This compound is of significant interest in pharmacological research and development due to its mechanism of action as a non-depolarizing muscle relaxant. It serves as a critical reference standard and research tool for neuroscientists, toxicologists, and pharmaceutical developers studying synaptic transmission, anesthetic adjuncts, and novel therapeutic agents.

Application

• Pharmacological Research: Used as a classic tool compound to study neuromuscular junction physiology and the competitive antagonism of nicotinic acetylcholine receptors.
• Neuroscience Studies: Employed in experimental models to induce reversible muscle paralysis for investigating central and peripheral nervous system functions.
• Toxicology Reference: Serves as a key reference standard in forensic and clinical toxicology for the identification and analysis of plant-derived neurotoxins.
• Drug Discovery: Acts as a lead compound or biochemical probe in the development of new muscle relaxants, anesthetics, and treatments for conditions like myasthenia gravis.
• Biochemical Assays: Utilized in in vitro receptor binding assays and enzymatic studies to screen for new compounds with modulatory activity.
• Academic & Educational Use: Applied in university and institutional laboratories for teaching advanced concepts in neuropharmacology and toxicology.

Basic Information

Product Name	Curare
CAS No.	8063-06-7
Molecular Formula	Complex mixture; primary alkaloids include Tubocurarine, C-Curarine I, C-Curarine II
Molecular Weight	Varies by alkaloid component (e.g., Tubocurarine chloride: 681.66 g/mol)
Synonyms	Curara; Curare Extract; Tube Curare; Intocostrin; d-Tubocurarine (primary component); Chondodendron tomentosum Extract; Pareira Brava; Ourari; Woorari; Wourali; Indian Arrow Poison; Amazonian Curare
EINECS	Contact for details

Quality Control

Our Curare is sourced and processed to meet the exacting standards required for research applications. Quality is assured through rigorous analytical testing, including chromatographic profiling to characterize the alkaloid composition. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity confirmation, and relevant biological activity data where applicable. We adhere to ISO 9001 quality management principles to ensure consistency and traceability for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Brown to dark brown resinous extract or solid
Identification (TLC/HPLC)	Conforms to reference profile for Curare alkaloids
Assay (Total Alkaloids)	≥ 90% (by Titration)
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 2.0 %
Biological Activity	Qualitative/Quantitative assay data available (e.g., frog sciatic nerve-gastrocnemius muscle preparation)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.