Description

Isosorbide Dinitrate CAS NO 87-33-2 is a potent organic nitrate ester widely recognized for its vasodilatory properties. This high-purity active pharmaceutical ingredient (API) is critical for the reliable and consistent formulation of cardiovascular medications. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for angina pectoris and congestive heart failure.

Application

• Pharmaceutical API: Core active ingredient in the formulation of sublingual tablets, oral tablets, and extended-release capsules for angina prophylaxis and treatment.
• Cardiovascular Research: Key reference standard and biochemical tool in pharmacological studies investigating vasodilation, nitric oxide donation, and smooth muscle relaxation mechanisms.
• Generic Drug Manufacturing: Essential for the production of cost-effective, bioequivalent generic versions of established anti-anginal medications.
• Hospital Compounding: Used in specialized pharmacy compounding for tailored patient dosages where commercial formulations are unsuitable.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control testing and method validation in analytical laboratories.

Basic Information

Product Name	Isosorbide Dinitrate
CAS No.	87-33-2
Molecular Formula	C6H8N2O8
Molecular Weight	236.14 g/mol
Synonyms	1,4:3,6-Dianhydro-D-glucitol 2,5-dinitrate; ISDN; Dinitrosorbide; Sorbide Nitrate; Isordil; Sorbitrate; 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate; D-Isosorbide Dinitrate
EINECS	201-740-9

Quality Control

Our Isosorbide Dinitrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with major pharmacopoeial standards such as USP and EP. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.