Description

2-Chloro-5-(Trifluoromethyl)Pyrazine is a high-purity, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents on a pyrazine core, makes it a critical intermediate for introducing specific pharmacophores and agrochemical motifs. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating functionalized heterocyclic compounds used in organic electronics and advanced polymer materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Pyrazine
CAS No.	799557-87-2
Molecular Formula	C5H2ClF3N2
Molecular Weight	182.53 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)pyrazine; 5-Chloro-2-(trifluoromethyl)pyrazine; 2-Chloro-5-trifluoromethylpyrazine; Pyrazine, 2-chloro-5-(trifluoromethyl)-; 799557-87-2; 2-Chloro-5-(trifluoromethyl)-1,4-diazine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Trifluoromethyl)Pyrazine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure containers are kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.