Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',5'-Bisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) analog. This compound is a critical biochemical tool for studying intracellular signaling pathways, membrane trafficking, and ion channel regulation. It is essential for researchers and developers in pharmaceutical discovery, lipidomics, and advanced cell biology, providing a defined standard for mechanistic studies and assay development.

Application

• Biochemical Research & Signal Transduction Studies: Used as a substrate or ligand to investigate the role of PI(3,5)P2 in cellular processes like endocytosis, autophagy, and osmoregulation.
• Lipid Kinase & Phosphatase Assay Development: Serves as a critical standard or substrate in enzymatic assays for drug screening and target validation.
• Membrane Biophysics: Incorporated into lipid bilayers or liposomes to study protein-lipid interactions and membrane dynamics.
• Pharmaceutical R&D: Employed in high-throughput screening (HTS) campaigns to identify modulators of phosphoinositide signaling pathways relevant to disease.
• Lipidomics Standard: Acts as a quantitative and qualitative reference standard in mass spectrometry-based lipid analysis.
• Cell Culture & Transfection Reagent Formulation: Can be used as a component in specialized lipid mixtures for gene delivery or membrane studies.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',5'-Bisphosphate) (Ammonium Salt)
CAS No.	799268-55-6
Molecular Formula	C47H89NO19P3 • xNH3
Molecular Weight	~1080.1 g/mol (free acid)
Synonyms	PI(3,5)P2 (18:1); DOPI(3,5)P2; 1,2-Dioleoyl-*sn*-glycero-3-phospho-(1D-*myo*-inositol-3,5-bisphosphate); Phosphatidylinositol 3,5-bisphosphate (DO); (3,5)PI; PtdIns(3,5)P2; Ammonium salt of 1,2-dioleoylphosphatidylinositol 3,5-bisphosphate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade biochemicals. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC), mass spectrometry confirmation, and lipid profile are available upon request. We adhere to strict in-house quality protocols to ensure batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (Mass Spec)	Complies
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform/methanol mixtures
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.