Description

tert-Butyl 4-(4-Amino-3-Methylbenzyl)Piperazine-1-Carboxylate is a high-purity, protected piperazine derivative featuring both a Boc-protected amine and a free aromatic amine group. This compound is a critical pharmaceutical intermediate valued for its versatility in multi-step synthetic routes, enabling the construction of complex bioactive molecules. It is primarily sought by research organizations and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly in therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for central nervous system (CNS) drugs, kinase inhibitors, and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new pharmacophores and improve drug-like properties.
• Custom Synthesis: Serves as a starting material or intermediate for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Chemical Biology Probes: Facilitates the creation of labeled or tagged molecules used to study biological pathways and target engagement.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns in drug discovery.

Basic Information

Product Name	tert-Butyl 4-(4-Amino-3-Methylbenzyl)Piperazine-1-Carboxylate
CAS No.	797792-59-7
Molecular Formula	C17H27N3O2
Molecular Weight	305.42 g/mol
Synonyms	1-Boc-4-(4-Amino-3-methylbenzyl)piperazine; tert-Butyl 4-[(4-Amino-3-methylphenyl)methyl]piperazine-1-carboxylate; 4-(4-Amino-3-methylbenzyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(4-amino-3-methylbenzyl)piperazine; N-Boc-4-(4-Amino-3-methylbenzyl)piperazine; BOC-4-(4-Amino-3-methylbenzyl)piperazine; 797792-59-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Amino-3-Methylbenzyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent identity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider using desiccants and maintaining an inert (nitrogen) atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.