Description

8-Phenyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine is a high-purity, advanced pharmaceutical intermediate featuring a fused triazolopyrazine heterocyclic core. This compound is of significant commercial interest for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications, particularly within the central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Used in the development and scale-up of new APIs, leveraging its unique triazolopyrazine structure.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for pharmacological studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design methodologies.

Basic Information

Product Name	8-Phenyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
CAS No.	794479-16-6
Molecular Formula	C14H13F3N4
Molecular Weight	294.28 g/mol
Synonyms	8-Phenyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; 794479-16-6; 5,6,7,8-Tetrahydro-8-phenyl-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine; [1,2,4]Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-8-phenyl-3-(trifluoromethyl)-; SCHEMBL2185427; BDBM50389395; AKOS025147319; A1-00806
EINECS	Contact for details

Quality Control

Our production of 8-Phenyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment. Our quality system is designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this moisture-sensitive material.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.