Description

(2-Hydroxymethyl-Piperidin-1-Yl)-Acetic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role as a key building block, offering a protected carboxylic acid group and a functionalized piperidine scaffold essential for modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of neurology and metabolic disease.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymes for therapeutic applications.
• Neurological Drug Discovery: Serves as a precursor in the synthesis of compounds targeting central nervous system (CNS) disorders.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Suitable for use in process research and development (PR&D) and pilot-scale manufacturing of candidate drugs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(2-Hydroxymethyl-Piperidin-1-Yl)-Acetic Acid tert-Butyl Ester
CAS No.	791642-61-0
Molecular Formula	C13H25NO3
Molecular Weight	243.34 g/mol
Synonyms	1-(tert-Butoxycarbonylmethyl)-2-hydroxymethylpiperidine; 2-(Hydroxymethyl)-1-piperidineacetic Acid 1,1-Dimethylethyl Ester; tert-Butyl 2-((2-(hydroxymethyl)piperidin-1-yl)acetate; (2-Hydroxymethyl-1-piperidyl)-acetic acid tert-butyl ester; N-Carboxymethyl-2-piperidinemethanol tert-Butyl Ester; BOC-Pip-OH; tert-Butyl (2-(hydroxymethyl)piperidin-1-yl)acetate
EINECS	Contact for details

Quality Control

Our (2-Hydroxymethyl-Piperidin-1-Yl)-Acetic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.