Description

1-Piperidinecarboxylicacid,4-Hydroxy-2-Methyl-,1,1-Dimethylethylester,(2S,4S)-(9Ci) is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its ability to introduce a specific spatial configuration into target molecules, which is essential for developing compounds with precise biological activity. This product is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological and cardiovascular diseases.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to construct enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize the pharmacophore of potential lead compounds.
• Peptidomimetics Development: Incorporated into the design of peptide-like molecules to enhance stability, bioavailability, and receptor binding affinity.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	1-Piperidinecarboxylicacid,4-Hydroxy-2-Methyl-,1,1-Dimethylethylester,(2S,4S)-(9Ci)
CAS No.	790667-99-1
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	(2S,4S)-4-Hydroxy-2-methylpiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl (2S,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate; (2S,4S)-1-Boc-4-hydroxy-2-methylpiperidine; (2S,4S)-N-Boc-4-hydroxy-2-methylpiperidine; (2S,4S)-4-Hydroxy-2-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; (2S,4S)-4-Hydroxy-2-methylpiperidine-1-carboxylic acid 1,1-dimethylethyl ester; (2S,4S)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-methylpiperidine
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylicacid,4-Hydroxy-2-Methyl-,1,1-Dimethylethylester,(2S,4S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.